Sep 2026
Rational design of chromeno[8,7-d]oxazoles as CDK16-directed inhibitors with improved solubility and antitumor activity.
Findings identify AT-11 as an early-stage chromeno[8,7-d]oxazole lead and extend the structure-activity basis for CDK16-directed inhibitor development.
Xu-Peng Yang, Cui-Bin Kong, Yao-Guang Huang et al.
· Bioorganic chemistry (Print) · 0 citations