PKM2 associated alveolar macrophage remodelling is linked to defective efferocytosis of apoptotic neutrophils in LPS induced acute lung injury.
BACKGROUND Impaired clearance of apoptotic neutrophils by alveolar macrophages (AMs) may sustain inflammation in acute lung injury (ALI). Although PKM2 regulates macrophage inflammatory responses, its relationship with AM efferocytic dysfunction during ALI remains unclear. METHODS We integrated time-course single-cel...