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Author

Xiaoyi Liu

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Conference Open access Sep 2026

Bridging the Biophysical Gap: Holistic Environmental Awareness for 3D Linker Design

LinkerBridge is proposed, an equivariant framework that unifies biochemical semantics with physical constraints through two innovations: a Contextual Interaction-Aware Representation module that internalizes pre-existing bio-chemical semantics and a Differentiable Physical Guidance mechanism derived from Van der Waals...

Meng-Wei Sun, Chengwei Ai, Xiao-Yi Liu et al. · 0 citations
Jul 2026

TextDTI: A Multimodal Context Representation Learning Framework for Drug-Target Interaction Prediction

This paper proposes TextDTI, a multimodal framework that simultaneously exploits sequential and structural representations and enhances feature alignment through adversarial learning and contrastive loss, resulting in robust and high-performance DTI prediction.

Jia-Qi Deng, Senyu Tang, Ji-Jun Tang et al. · 0 citations

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