Tetramethylpyrazine alleviates oxidative stress-induced nerve injury by promoting mitophagy through miR-144-5p/Panx1 following spinal cord injury.
BACKGROUND Ligusticum sinense 'Chuanxiong', a Chinese medicinal herb, has long been used clinically to treat injuries. Its primary active compound, tetramethylpyrazine (TMP), has been demonstrated to mitigate oxidative damage in spinal cord injury (SCI) and is emerging as a potential therapeutic agent. However, transla...