Open access
Oct 2026
TRIM2 negatively regulates antiviral immunity by degradation of MDA5 and STAT2 during influenza A virus infection
This study identifies TRIM2 as an interferon-stimulated gene (ISG) regulated by both type I and type II interferons. Contrary to the typical antiviral role of most ISGs, TRIM2 significantly enhances influenza A virus (IAV) replication both in vitro and in vivo. Mechanistically, TRIM2 functions as a negative regulator...
Yu-Ying Zhang, Hao-Ning Li, Yao Wang et al.
· Cell Death & Disease · 0 citations