Author

Xiao-Yan Lin

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Open access Sep 2026

Fibroblast-associated TPM2 links cell-matrix remodeling to EMT-Notch signaling and gemcitabine resistance in intrahepatic cholangiocarcinoma

ABSTRACT Background Intrahepatic cholangiocarcinoma (ICC) is an aggressive liver malignancy with heterogeneous responses to gemcitabine-based chemotherapy. The cellular and microenvironmental programs associated with the gemcitabine response remain incompletely understood. This study aimed to identify tumor microenviro...

Ying-Jiao Zhu, Zhi-Bin Qiao, Zhu-Hong Chen et al. · Cancer Biology & Therapy · 0 citations

Sep 2026

c-MET/NF-κB axis modulates PD-L1 and CCL22-mediated immune evasion and its inhibition enhances anti-PD-1 efficacy in non-small cell lung cancer.

BACKGROUND c-MET overexpression is common in non-small cell lung cancer (NSCLC) and associated with poor prognosis, however, its role in immune evasion and immunotherapy resistance remains unclear. METHODS We analyzed c-MET expression in public "The Cancer Genome Atlas NSCLC" cohort (n = 1043) and an institutional co...

Li-Jin Chen, Xi-Hu Yao, Chun-Yan Su et al. · International Immunopharmaco... · 0 citations