Review
Open access
Aug 2026
Histone modifications: mechanisms, metabolic regulation, and therapeutic targeting in cancer
This review comprehensively summarizes the multifaceted roles of major histone modifications, including acetylation, methylation, ubiquitination, phosphorylation, and emerging metabolism-linked acylations, in governing critical DNA-templated processes such as replication, transcription, and the DNA damage response.
Ling-Li Wang, Shi-Ying Li, Xiao-Yan Hu et al.
· Precision Clinical Medicine · 0 citations