Xiao-Ya Li

Microglia in Alzheimer’s disease: from pathogenic mechanisms to therapeutic targeting

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder driven by β-amyloid (Aβ) deposition, tau hyperphosphorylation, synaptic dysfunction, neuroinflammation, vascular injury, and metabolic dysregulation. Recent advances in single-cell, spatial, and multi-omics transcriptomics have substantially reshap...