Author

Xiao-Xue Chen

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Aug 2026

Targeting Ferroptosis and Cuproptosis in Ulcerative Colitis: Findings from Comprehensive Bioinformatics and Experimental Validation.

Ulcerative colitis (UC) is a persistent intestinal disorder with an incompletely defined pathogenesis and increasing prevalence and hospitalization rates in newly industrialized countries. In UC, excessive intestinal epithelial cell death disrupts the mucosal barrier and triggers inflammatory responses. Ferroptosis and...

Xiao-Xue Chen, Zhantu Hu, Qian-Ye Wang et al. · Journal of Visualized Experi... · 0 citations

Open access Jul 2026

STC1 is associated with tumor progression and suppressive niches in laryngeal squamous cell carcinoma

Background Laryngeal squamous cell carcinoma (LSCC) exhibits high recurrence and therapy resistance. We aimed to investigate the undefined role of Stanniocalcin-1 (STC1) in LSCC pathogenesis. Methods The single-cell RNA sequencing (RNA-seq) data and the clinical information of LSCC patients were acquired from the publi...

Xiao-Xue Chen, Wen-Jing Li, Yi-Yao Liu et al. · Translational Cancer Researc... · 0 citations

#protein folding Open access Aug 2026

Ribosome engineering enhances genetic code expansion in Saccharomyces cerevisiae

Genetic code expansion enables the site-specific installation of noncanonical amino acids (ncAAs) into proteins, but its limited efficiency in eukaryotes remains a major barrier to broader application. Here we establish a visual, plug-and-play screening platform to evolve 18S ribosomal DNA in Saccharomyces cerevisiae a...

Xiao-Xu Chen, Wentao Shen, Xian-Qing Chen et al. · Synthetic and Systems Biotec... · 0 citations