Cascade-Catalytic MnO2 Nanoreactor Amplifies Oxidative Stress and Activates cGAS-STING Pathway To Remodel the Immunosuppressive Microenvironment of Triple-Negative Breast Cancer.
Triple-negative breast cancer (TNBC) is characterized by a highly immunosuppressive tumor microenvironment, which severely limits the therapeutic efficacy of current immunotherapies. To address this challenge, we developed a hyaluronic acid-modified tumor-targeted MnO2 nanoreactor (HMGR@HA) for the codelivery of GOx an...