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Author

Xiao-Xin Sun

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Open access Aug 2026

GNL3 SUMOylation is essential for DNA double-strand break repair by homologous recombination

DNA double-strand break repair via homologous recombination is critical for maintaining genomic integrity and requires proper DNA end resection. Here, we identify GNL3, a nucleolar GTP-binding protein, as a key regulator of homologous recombination in human cells via SUMOylation-dependent control of DNA end resection....

Yun-Han Yang, Yan-Ping Li, Roselyn S. Dai et al. · 0 citations
Sep 2026

Abstract B126: Targeting USP36 as a therapeutic strategy for high-MYC expressing pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, characterized by poor therapeutic response and aggressive disease progression driven heavily by the c-MYC oncoprotein. Ubiquitin-specific protease 36 (USP36) is a nucleolar deubiquitinating enzyme that enhances the stability of criti...

Assmaa ElSheikh, Ping-Chuan Zhang, Xiao-Yan Wang et al. · 0 citations

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