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Xiao-Xiao Tang

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2 papers indexed here

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Open access Oct 2026

The PIEZO1/CISD1/IP3R Mechanotransduction Axis Drives Macrophage Mitochondrial Dysfunction and Inflammatory Activation in Pulmonary Fibrosis

ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease characterized by excessive extracellular matrix (ECM) deposition and elevated tissue stiffness. While aberrant mechanotransduction is increasingly recognized as a key driver of fibrotic progression, the mechanisms by which...

Yun-Geng Wei, Chao Xie, Xiang-Sheng Yang et al. · 0 citations
Review Open access Oct 2026

The role and mechanism of macrophage-to-myofibroblast transition in fibrotic diseases

Fibrosis is a pathological process primarily characterized by excessive deposition of extracellular matrix (ECM), which leads to disruption of tissue architecture and progressive loss of organ function, serving as a key pathological basis for various chronic diseases. Recent studies have revealed that, in addition to c...

Hua Guo, Xiao-Xiao Tang · 0 citations

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