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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Xiao-Wen Lin

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Open access Sep 2026

Multi-omics and experimental validation identify RAPGEF2 as a protective prognostic biomarker in clear cell renal cell carcinoma

Highlights • Single-cell, spatial transcriptomic and multi-omics analyses reveal endothelial-enriched RAPGEF2 in KIRC.• RAPGEF2 independently predicts favorable survival across multicenter KIRC cohorts.• Experimental validation links RAPGEF2 to tumor suppression and immunotherapy benefit.

Yan-Fei Chen, Xiao-Xue Yu, Chao Cai et al. · 0 citations

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