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Xiao-Qing Lian

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Open access Sep 2026

UpTCR: a unified progressive knowledge transfer foundation model for robust T-cell receptor-antigen binding recognition

T-cell receptor (TCR) recognition of antigenic peptides presented by human leukocyte antigen (HLA) molecules underpins adaptive immunity and T cell-based immunotherapy. However, the scarcity of complete interaction data and TCR cross-reactivity challenge robust prediction. Here, we present UpTCR, a unified progressiv...

Tian-Xu Lv, Yang Xiao, Li Chen et al. · 0 citations

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