Open access
Sep 2026
ACAD8-mediated valine catabolism inhibits mTOR signaling to suppress lipid accumulation and progression of clear cell renal cell carcinoma
Highlights • WGCNA identified a lipid and branched-chain amino acid metabolism–related module closely associated with ccRCC clinical features.• ACAD8 was identified as a key gene downregulated in ccRCC, with low expression predicting poor prognosis.• ACAD8 suppressed ccRCC proliferation, migration, invasion, and lipid...
Run-Kun Fan, Zi-Rui Dong, Wei-Song Wu et al.
· Translational Oncology · 0 citations