Author

Xiao-Ning Zhao

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Open access Sep 2026

Vagus Nerve Stimulation Exerts Disease-Modifying Effects in Epileptic Rats by Enhancing Hippocampal Adenosine Signalling.

OBJECTIVES Vagus nerve stimulation (VNS) is an established neuromodulatory therapy for refractory epilepsy, but its disease-modifying mechanisms remain unclear. Adenosine is an endogenous anticonvulsant and a key regulator of epileptogenesis, and adenosine kinase (ADK) controls extracellular adenosine availability. Thi...

Zhong-Hua Xiong, Jing Zhang, Ran Gao et al. · Brain Stimulation · 0 citations

Jul 2026

Discovery of a Potent, Orally Bioavailable Small-Molecule Inhibitor of Wildtype KIT with Exceptionally High Kinome Selectivity.

A highly selective small-molecule KIT inhibitor is described that exhibits excellent broad kinome selectivity, with a selectivity score of S(50%) = 0.003, demonstrated promising in vivo therapeutic efficacy in an SCF-driven acute cutaneous anaphylaxis model in rodents.

Karen Y. Chen, Shiwei Qu, Xue-Lei Yan et al. · Journal of Medicinal Chemist... · 1 citation