Open access
Aug 2026
TRIM25 facilitates mitochondrial dysfunction and extracellular matrix degradation by enhancing USP7‐driven ENO1 deubiquitination during intervertebral disc degeneration
Both cellular and animal models confirm that intervention in the TRIM25/USP7/ENO1 axis effectively reverses metabolic imbalance and degenerative progression, offering a promising new therapeutic strategy for IDD.
Xiao-Ming Liu, Wen-Yu Zhang, Hang Feng et al.
· Clinical and Translational M... · 0 citations