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Xiao-Man Li

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Open access Aug 2026

Targeting breast cancer stem cells by restoring RBM38 function: mechanism and protein delivery therapy

Breast cancer stemness drives tumor progression and therapy resistance, yet the underlying mechanisms remain poorly understood. In this study, we observed that RBM38 expression gradually decreases during breast cancer progression in MMTV-PyMT transgenic mice. Using a model with targeted RBM38 expression in breast tissu...

Jun Yin, Ting Wang, Xuedan Han et al. · 0 citations
Jul 2026

Discovery of natural product-derived rosavin as a programmed death-ligand 1 inhibitor for cancer immunotherapy.

Rosavin is identified as a privileged novel and unexpected scaffold for designing potent PD-1/PD-L1 modulators, offering promising candidates for cancer immunotherapy and exhibiting the unusual small-molecule property of inhibiting PD-L1 without inducing its dimerization.

Wei Zou, Tianle Li, Jacek Plewka et al. · 0 citations

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