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Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy
ABSTRACT Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. In this study, we put forward a novel antifungal strategy that targets the conserved global secondary metabolic pathway in pathogenic...
Molecular engineering of a cold-active xylanase TsTA1 from a straw-decomposing fungus Talaromyces stipitatus.
These findings enhance the understanding of straw decomposition by cold-adapted microbes and demonstrate a successful strategy for improving enzyme performance under challenging environmental conditions.