Author

Xiao-Lin Xu

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Review Open access Aug 2026

Bidirectional associations between loneliness and physical multimorbidity and the mediating role of social inactivity

Physical multimorbidity and loneliness are increasingly recognised as public health concerns, but the nature of their potential relationships remains unclear. Here we report bidirectional associations between physical multimorbidity and loneliness in middle-aged and older adults and the mediating role of social inactiv...

Ya-Guan Zhou, Si-Qi Zhu, J. Holt-Lunstad et al. · Nature Communications · 0 citations

Open access Aug 2026

Trajectories of physical function, depressive symptoms, and cognitive performance before and after falls in older adults: A matched multicohort study

In older adults, multidomain functional decline appears to precede falls by several years and worsens further after fall events, which may signal broader functional deterioration and highlight the need for prevention and management strategies addressing physical, psychological, and cognitive domains.

Jun-Jie Lin, M. Kivimäki, Zi-Fan Zhang et al. · PLoS Medicine · 0 citations

Open access Aug 2026

Sex inequality in disease burden attributable to smoking, secondhand smoke and chewing tobacco: A systematic analysis for the Global Burden of Disease Study 2023

Decomposition analysis showed that population growth and aging were the predominant drivers of increasing absolute DALYs in both sexes, with consistently larger effects among males, while change in risk exposure contributed differently to sex-specific burden trajectories across the three tobacco risks.

Sheng Li, Zhe Xu, Brooks Morgan et al. · EClinicalMedicine · 0 citations