Design, Synthesis, and Antifungal Activity of Novel Oxadiazole-Pyrazole-Triazole Derivatives: Insights into Cellular Disruption Revealed by Integrated Transcriptomic and Proteomic Analyses.
Resistance to single-target fungicides necessitates structurally innovative antifungal agents with broadened modes of action. Herein, a series of pyrazole-oxadiazole-linked 1,2,4-triazole derivatives (L1-L39) were designed and synthesized via molecular hybridization. Compound L22 exhibited exceptional activity against...