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Author

Xiao-Li Liu

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3 papers indexed here

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Oct 2026

Monofluoromethylphenylalanine: A Sensitive 19F Probe for Protein Conformational Dynamics In Vitro and in Cells

The combination of site-specific incorporation of 19F-labeled unnatural amino acids (UAAs) and 19F nuclear magnetic resonance (NMR) spectroscopy is a powerful strategy for investigating protein structure, dynamics, and interactions. However, commonly used 19F-containing UAAs often suffer from narrow chemical shift di...

Pan Shi, Jun Liang, Xiao-Li Liu et al. · 0 citations
Aug 2026

Photo-CIDNP-Enhanced 19F NMR for Rapid Protein Conformation and Ligand Binding Analysis.

19F NMR spectroscopy is a powerful probe of protein conformation and dynamics but is intrinsically limited by low sensitivity common to other NMR techniques. Here, we integrate photochemically induced dynamic nuclear polarization (photo-CIDNP) with genetically encoded 19F labels to enhance sensitivity by up to 220-fold...

Zhao-Fei Chai, Weixuan Wang, Qiong Wu et al. · 1 citation
Open access Aug 2026

Assessing G‑Quadruplex Stability and Nonspecific Interactions in Living Cells Using 19F NMR

It is found that G4 structural stability, interactions, and NMR signal detectability are cell-type-dependent, and it is demonstrated that cell lysates can serve as a practical platform for reflecting G4 stability in intact cells.

Qiong Wu, Wen-Wen Zheng, Chen Wang et al. · 0 citations

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