Author

Xiao-Hua Wan

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Open access Sep 2026

CryoFlex characterizes structural motion between conformations directly from cryo-EM density maps

Heterogeneous cryo-EM reconstruction methods can resolve multiple conformational states, but understanding their functional implications often requires determining which regions move between states and quantifying their displacement magnitudes. Comparing atomic models can quantify motion, but flexible regions are often...

Hao Dong, Fu-Wei Li, Yuan-Bo Chen et al. · bioRxiv · 0 citations

Open access Sep 2026

CryoMV: Structure-Prior-Guided Modeling and Real-Particle Validation of Continuous Conformational Transitions in Cryo-EM

Continuous protein conformations are essential for understanding fundamental biological processes and supporting drug discovery. Although cryo-EM can resolve individual states at high resolution, recovering continuous heterogeneity from 2D particle images remains challenging. High noise, motion blur, and limited struct...

Fu-Wei Li, Hao Dong, Shuai Tang et al. · bioRxiv · 0 citations