Author

Xiao-Hong Wu

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Open access Aug 2026

Genome-wide annotation of human multi-nucleotide variants reveals widespread functional differences from single nucleotide variants

Multi-nucleotide variants (MNVs) represent a crucial yet underexplored category of genetic variation. Despite previous studies highlighting the prevalence and potential biological impact of MNVs in populations, comprehensive identification and detailed functional annotation of MNVs remain challenging. Here, we develop...

Wei-Wei Jin, Wen Cao, Hao-Hui Luo et al. · Nature Communications · 0 citations

Open access Sep 2026

Large-scale pleiotropic analysis across cancers reveals shared genetic mechanisms and identifies novel functional genes

Using summary statistics from genome-wide association studies for 37 cancer types, extensive genome-wide and local genetic correlations among cancers are identified and 33 novel functional genes harboring previously unreported cancer risk variants are identified.

Xiao-Hong Wu, Yu-Qing Yan, Wen Cao et al. · Briefings in Bioinformatics · 0 citations