Nucleoside-based anticancer drugs are still needed to treat solid tumours and blood cancers, but due to systemic toxicity and the emergence of resistance, they have performed poorly in clinical practice. These agents inhibit deoxyribonucleic acid (DNA) synthesis, disrupt ribonucleic acid (RNA) metabolism, or deplete nu...
Chun-Yuan Gan, Jin-Hu Xiang, Yao-Hua Liu et al.· Biochemical Pharmacology· 0 citations
Metastatic breast cancer remains a major therapeutic challenge due to the limited efficacy of current treatments against both primary tumors and distant metastases. Here, we developed an arginine-based click-crosslinked nanoplatform for the co-delivery of camptothecin (CPT) and STAT3 siRNA (siSTAT3). The nanoplatform w...
Su-Bin Xiong, Jin-Hu Xiang, Xiao He et al.· International journal of pha...· 0 citations
This review summarizes recent advances in delivery to the lungs, spleen, brain, heart, kidney, bone, and pancreas, discusses major translational bottlenecks, and proposes a direction for predictive design.
Yu Liu, Xiao Guo, Qin Hu et al.· Materials Today Bio· 0 citations
In vitro and in vivo evaluations confirm that R-A/G@Z effectively suppresses aggressive breast tumors while maintaining a good safety profile, offering a promising strategy for intelligent metabolic-chemodynamic cancer nanomedicine.
Nian-Ting Xiao, Xiao He, Da-Xiu Li et al.· Journal of Colloid and Inter...· 0 citations
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