AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
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A scalable physics-based framework that combines field-aware machine learning with molecular mechanics to capture enzyme electrostatics at quantum-mechanical accuracy while enabling efficient, atomistic exploration of reaction free-energy landscapes is presented.
This Account identified the G-protein-coupled receptor MRGPRX4 (hX4) as a human bile acid receptor mediating cholestatic pruritus and demonstrated that sulfated bile acids are key endogenous pruritogens that accumulate in patients with cholestasis.
A key mechanism underlying SL-repressed drought acclimation in rice is uncovered and genome editing of key components in SL pathway enhances drought resistance in NP, Huazhan (HZ), and IRAT109 and provides an effective strategy to improve drought resistance in diverse rice varieties amid ongoing climate change.
This review summarizes major advances in enzyme discovery in plant natural product biosynthesis in recent years, focusing on emerging catalytic mechanisms, strategies for elucidating pathways, and evolutionary relationships, and highlights their implications for synthetic biology, metabolic engineering, and the sustain...
A novel polypeptide-based platform that substantially increases the DAR of antibody-payload ADCs while minimally compromising the ADCs’ inherent characteristics is presented and a highly variable polypeptide backbone platform is characterizes.
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