Xiao-Ge An

USP40 alleviates atherosclerosis by stabilizing SIRT1 to suppress endothelial apoptosis and NLRP3 inflammasome activation.

Atherosclerosis (AS) is a chronic inflammatory vascular disease driven by endothelial dysfunction, and dysregulated ubiquitination has emerged as an important pathogenic mechanism. Although deubiquitinating enzymes (DUBs) are key regulators of protein homeostasis, the role of USP40 in AS remains unknown. Here, we defin...