Toll-like receptors are important components of the pattern recognition receptor (PRR) family, and Toll-like receptor 2 (TLR2) is one of the most important Toll-like receptors involved in defending against infection and injury. TLR2 senses a wide array of pathogen- and damage-associated molecular patterns and has very...
Chen-Yu Le, Xiu-Lin Dong, Ying Bian et al.· Biochemical Pharmacology· 0 citations
Background: Although non-ampullary duodenal epithelial tumors (NADETs) were historically considered rare, their detection has increased with high-resolution and image-enhanced endoscopy. Endoscopic resection is the preferred organ-preserving treatment for lesions without evidence of nodal metastatic risk, but the thin,...
Huan-Lu Xu, Rong Hu, Ke-Cheng Jiang et al.· Gastrointestinal Disorders· 0 citations
Traditional metabolic inhibitors have limited clinical efficacy, with issues such as narrow window periods, and compensatory effects. These barriers indicate that effective metabolic therapy requires spatially restricted, temporally coordinated, cell-context-aware, and clinically stratifiable intervention. This review...
