Author

Xiao-Fei Shi

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Open access Aug 2026

EBV-driven Gate–License–Amplify circuit in multiple sclerosis pathogenesis

Five recent publications establish a “ Gate – License – Amplify ” circuit that mechanistically links Epstein – Barr virus (EBV) infection and genetic risk (HLA-DR15) to the pathogenesis of multiple sclerosis (MS). 1 – 5 This new model reveals how EBV reprograms immuno-peptidomes to trigger CNS autoimmunity, providing a...

Yuxin Li, Xiao-Fei Shi, Yu-Xiao Zhang et al. · Signal Transduction and Targ... · 0 citations

Review Open access Sep 2026

Targeting FOXP3 and Regulatory T Cells in Systemic Lupus Erythematosus: Emerging Therapeutic Strategies and Clinical Prospects

It is proposed that the precise modulation and enhancement of Treg function to restore stable immune tolerance in SLE patients constitutes a novel therapeutic paradigm, transitioning from broad immunosuppression toward targeted immune modulation.

Shu-Shu Du, Wen-Qi Xu, Li-Li Zhao et al. · Journal of Cellular Biochemi... · 0 citations