CPNE8 Suppresses Hepatocellular Carcinoma Progression Through Downregulation of ITGB1/CDC42/PAK1 Signaling and an Altered Immune-Marker Profile
Background: Hepatocellular carcinoma (HCC) is among the most lethal malignancies, and its immunosuppressive microenvironment limits the efficacy of current therapies. The integrin β1 (ITGB1)-CDC42-p21-activated kinase 1 (PAK1) axis is an established driver of HCC progression; however, the role of copine 8 (CPNE8), a ca...