Open access
Sep 2026
Structural basis for broad orthopoxvirus neutralization by two antibodies targeting distinct L1R epitopes.
The 2022 mpox outbreak highlights the persistent threat posed by the mpox virus (MPXV) and related orthopoxviruses (OPXVs). Yet, approved antibody-based therapeutics for OPXVs are lacking. Here, we present two broadly neutralizing monoclonal antibodies (mAbs), G4 and B9, that target the MPXV M1R protein, homologous to...
Li Chen, Guan-Ying Zhang, Hao-Tian Lin et al.
· Cell Reports Medicine · 0 citations