Xiao-Chun Huang

The FOXA2/ST3GAL4 axis regulates airway mucus hypersecretion by modulating the ERK/NF-κB pathway.

Airway mucus hypersecretion is a pathophysiological process characterized by excessive mucus production driven by diverse pathogenic factors, which exacerbates clinical outcomes in susceptible populations by increasing morbidity and mortality. MUC5AC, the predominant mucin secreted by airway goblet cells, serves as one...