Xiao-Bo Wu

S-equol Mitigates Anxiety-like Behaviors Associated with Acute Hyperuricemia by Restoring Neuronal Excitability in the Medial Prefrontal Cortex.

Hyperuricemia (HUA) is a prevalent metabolic disorder closely linked to neuropsychiatric symptoms, including emotional disturbances. However, the neural mechanisms underlying this association remain largely unexplored. We established a mouse model of acute HUA by administering potassium oxonate (PO) and hypoxanthine (H...