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Xiangyu Ma

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Open access Oct 2026

Design, synthesis of a novel ginsenoside derivative and its protection against acetaminophen induced liver injury via suppressing HIF1α-mediated glycolytic metabolism

Acetaminophen (APAP) overdose is a leading cause of drug-induced liver injury (DILI). Inspired by the synergistic hepatoprotective effects of (20S, 24R)-ocotillol (OC) and lipoic acid (LA), we designed and synthesized OCLA, a novel ginsenoside derivative that has been granted a patent. The structure of OCL...

Liu Han, Qiu-Yue Zhang, Wei Shang et al. · 0 citations
Review Open access Jul 2026

Tumor cells escape from therapy-induced senescence: from molecular mechanisms to targeted intervention.

This review systematically elucidates the multidimensional molecular regulatory networks through which senescent tumor cells promote tumor recurrence, encompassing key processes such as cell cycle reactivation mechanisms, epithelial-mesenchymal transition (EMT), acquisition of stemness phenotypes, formation of polyploi...

Yu Han, Lie Ma, Xiangyu Ma · 0 citations

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