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Author

Xiang-Yang Chi

2 papers indexed here

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Open access Sep 2026

Structural basis for broad orthopoxvirus neutralization by two antibodies targeting distinct L1R epitopes.

The 2022 mpox outbreak highlights the persistent threat posed by the mpox virus (MPXV) and related orthopoxviruses (OPXVs). Yet, approved antibody-based therapeutics for OPXVs are lacking. Here, we present two broadly neutralizing monoclonal antibodies (mAbs), G4 and B9, that target the MPXV M1R protein, homologous to...

Li Chen, Guan-Ying Zhang, Hao-Tian Lin et al. · 0 citations
Open access Oct 2026

Single-Cell BCR and Transcriptome Analysis Revealed Potent Neutralizing Antibodies in Response to HAdV-4 Infection

Human adenovirus type 4 (HAdV-4) is a predominant serotype causing acute respiratory infections, for which no antibody drugs have been clinically approved to date, resulting in an urgent unmet medical need. This study aimed to identify highly potent neutralizing antibodies by dissecting the B cell immune response after...

Ting-Ting Yu, Xiao-Lei Ye, Zheng Zhu et al. · 0 citations

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