Open access
Oct 2026
Endogenous APP-Associated Proteomics in Mouse Brain Defines a Candidate Resource for APP Trafficking and Proteostasis Studies
Background/Objectives: Affinity proteomics of amyloid precursor protein (APP) is complicated by proteolytic processing, dynamic trafficking, and purification background. We generated a C-terminal 3×FLAG knock-in at the endogenous App locus to establish a cortical affinity-proteomic resource and prioritize APP-associate...
Ye-Ting Zeng, Shu-Shan Wei, Ke-Yi Hu et al.
· Biomedicines · 0 citations