3-Indoleacetonitrile inhibits Singapore grouper iridovirus via dual mechanisms: direct interference with viral life cycle and activation of IRF3-mediated type I interferon response.
Findings demonstrate that 3-indoleacetonitrile inhibits SGIV infection through both direct antiviral action and activation of the IRF3-mediated type I IFN pathway, suggesting its potential as a natural candidate for the prevention and control of grouper iridovirus disease.