Xiang Meng

A Cosine-Projection Framework for Choosing Among Cox HR, D-RMST, and Average-Hazard Tests in Survival Trials

The log-rank/Cox hazard-ratio test remains the standard approach for the primary analysis of randomized trials with time-to-event endpoints and is fully efficient under proportional hazards (PH). Two model-free alternatives that have recently gained attention are the difference in restricted mean survival time (D-RMST)...