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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

Xiang Luo

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Open access Sep 2026

PLXDC2 siRNA‐Mediated Intervention Attenuates Microglial Senescence Through cGAS‐STING Signaling

ABSTRACT Parkinson's disease (PD) is driven by neurodegeneration, iron accumulation, and microglial senescence, yet effective therapy is hindered by the blood–brain barrier (BBB). By constructing the largest‐to‐date single‐cell atlas of the human substantia nigra, we identified a marked upregulation of PLXDC2 in PD mic...

He-Yue Lu, Zi-Tian Zheng, Fei-Ran Wang et al. · 0 citations
Open access Sep 2026

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

ABSTRACT Idiopathic pediatric uveitis (IPU) is a leading cause of irreversible vision loss in children; however, the genetic and molecular mechanisms underlying this condition remain unclear. Herein, trio‐based whole‐exome sequencing was performed in 28 affected families and targeted sequencing was performed in 1953 sp...

Qian Zhou, Jia-Xing Huang, Yi-Lin Wang et al. · 0 citations

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