The oral–lung axis describes microbial and inflammatory exchange between the oral cavity and the lower respiratory tract. Its relevance to lung cancer is supported by the detection of oral-associated taxa in lower-airway samples, epidemiological links between periodontal disease and lung cancer risk, and experimental e...
Xiang-Liang Liu, Guan-Ran Ding, Jin Lu et al.· Frontiers in Immunology· 0 citations
Higher UPF consumption is associated with increased atherosclerosis risk and support dietary recommendations emphasizing minimally processed foods for cardiovascular disease prevention and highlight candidate molecular correlates requiring independent validation.
Yi-Xin Zhao, Yu-Guang Li, Xiang-Liang Liu et al.· Frontiers in Nutrition· 0 citations
Circulating tumor DNA currently functions mainly as a prognostic and response-associated biomarker in lung cancer immunotherapy, while its predictive, decision-defining role remains an important but investigational objective.
Yan Li, Guan-Yu Lu, Wei Song et al.· Frontiers in Immunology· 0 citations
The need for prospective validation and multidisciplinary collaboration to translate advances in radiomics, AI, liquid biopsy, airway classifiers, and multi-omics integration into clinically useful pathways that improve early lung cancer detection, reduce unnecessary interventions, and enhance patient outcomes is highl...
Yan Li, Guan-Yu Lu, Xiang-Liang Liu et al.· Critical reviews in oncology...· 0 citations
This review examines how tumor-derived signals activate IRE1α/XBP1 to upregulate both the autophagy-lysosome pathway (ALP) and ubiquitin-proteasome system (UPS); its crosstalk with inflammatory and metabolic networks; and the therapeutic potential of IRE1α inhibitors, XBP1-directed strategies, and nutritional approache...
Guan-Ran Ding, Wang Yang, Yi-Xin Zhao et al.· Biochimica et biophysica act...· 0 citations
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