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Xiang-Dong Cheng

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Open access Oct 2026

Antibody–drug conjugates in solid tumors: current landscape, challenges, and future directions

The emergence of bispecific ADC, immune-stimulating ADC platforms, and next-generation payload designs are now driving the evolution of ADC technology toward broader patient applicability and improved safety profiles, which hold the potential to translate into new therapeutic opportunities for patients with high-incide...

Teng Yang, T. Shimura, Qing Wei et al. · 0 citations
Aug 2026

Zwitterionic Brush-Engineered Molecular Spherical Nucleic Acids for Enhanced Intracellular Antisense Activity.

Spherical nucleic acids (SNAs) enhance antisense oligonucleotide (ASO) uptake and nuclease resistance, but their activity is often constrained by inefficient intracellular trafficking. Here, we developed a zwitterionic brush-engineered molecular SNA (EmSNA) to improve ASO delivery. EmSNA was constructed by grafting pol...

Rui Xu, Xiu-Ying Sun, Li Yan et al. · 0 citations

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