Author

Xiang Chen

2 papers indexed here

We haven’t gathered this author’s papers yet. Follow them and we’ll fetch their work.

Not the right person? Other researchers publish under this name.

Open access Oct 2026

Protocol for detecting germline copy number variants from whole-exome sequencing using agent-assisted Snakemake workflows.

Germline copy number variants (gCNVs) are vital for diagnosing rare monogenic disorders. Here, we present a containerized, agent-assisted Snakemake protocol for detecting, annotating, and visualizing gCNVs from short-read whole-exome sequencing data. We describe steps for constructing baseline models, executing CNV cal...

Xiang Chen · STAR Protocols · 0 citations

Open access Sep 2026

Comprehensive evaluation of structural variation detection for germline and somatic analysis with long-read sequencing data

Abstract Detecting structural variations (SVs) via long-read sequencing remains difficult due to algorithmic variations and genomic complexity, alongside a shortage of comprehensive benchmarks for somatic variants. We present a unified benchmarking framework covering both germline and somatic SV detection, which evalua...

Hua Shi, Yi-Hang Lin, Da-Chen Liu et al. · Briefings in Bioinformatics · 0 citations