Xiang-Bo Wan

A cuproptosis-inducing covalent organic framework synergizes with oncolytic virus for tumor radiotherapy

Acquired radioresistance limits effective radiotherapy. Cuproptosis is a copper-dependent form of cell death driven by mitochondrial copper accumulation and lipoylated protein aggregation. Building on evidence that radioresistant cancer cells exhibit increased cuproptosis susceptibility, here we combine a radiation-res...