Aug 2026
Thumpd1 preserves osteogenic TGF-β signaling by promoting USP4-dependent deubiquitination and stabilization of TGF-βRII.
Impaired osteogenic signaling contributes to defective bone formation, but the mechanisms that preserve receptor stability during skeletal development remain incompletely understood. We investigated the role of Thumpd1 in skeletal development and osteogenic differentiation and defined the downstream signaling mechanism...
Donglun Xiao, Hou-Zhi Yang, Dongliang Zhang et al.
· Biochemical Pharmacology · 0 citations