Intratumoral microbiota are emerging as important ecological components of the colorectal cancer (CRC) microenvironment. However, their stage–associated patterns and coordination with host gene expression remain poorly understood. This study aimed to characterize stage–associated associations between intratumoral m...
Zhi-Yuan Chen, Wen-Xuan Gan, Fang Cao et al.· Frontiers in Microbiology· 0 citations
The liver has a remarkable regenerative capacity, but persistent injury caused by drugs, metabolic dysfunction, alcohol, and chronic inflammation can overwhelm this process and promote fibrosis and hepatocellular carcinoma. Interleukin-11 (IL-11), a cytokine that signals through glycoprotein 130 (gp130), was historical...
Zhi-Yuan Chen, Fan Yu, Yan-Hua Qiu et al.· Biomolecules· 0 citations
This review starts with the historical background and biological features to classify mainly the liquid biopsy biomarkers, such as circulating tumor DNA, circulating tumor cells, extracellular vesicles, non-coding RNAs, tumor-educated platelets and tumor-associated antigens, and also summarizes the present classificati...
Early detection of obstructive sleep apnea (OSA) in adults with metabolic dysfunction associated steatotic liver disease (MASLD) remains a clinical challenge. Plasma proteomics provides a non-invasive tool for identifying individuals at elevated risk prior to symptom onset. We quantified 2911 plasma proteins in 17 375...
Yujun Luo, Jia-Yu Huang, Ruiping Chen et al.· The FASEB Journal· 0 citations
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