Spatial Heterogeneity in Anaplastic Thyroid Carcinoma: Mechanistic Insights and Clinical Translation through Single-Cell and Spatial Transcriptomics.
Anaplastic thyroid carcinoma (ATC) is a highly lethal malignancy whose therapeutic resistance is driven by profound intra-tumor heterogeneity and a complex tumor microenvironment. This review synthesizes how single-cell and spatial transcriptomic technologies are transforming our understanding of ATC by systematically...