Open access
Aug 2026
Social isolation recruits amygdala–medial prefrontal cortex projections to escalate alcohol drinking in male mice
It is shown that isolation escalates alcohol drinking in male mice but suppresses it in females, and a BLA–mPFC pathway mechanism through which social isolation reconfigures prefrontal processing to promote alcohol intake is identified.
Reesha R. Patel, Kelly N. Kim, Makenzie Patarino et al.
· Nature Neuroscience · 1 citation