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Author

Xian-Liang Wang

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Open access Sep 2026

miR-133a deficiency is associated with cardiac and skeletal muscle remodeling and enhanced Fosl-2/TGF-β1/Smad3-related profibrotic signaling in ischemic heart failure

Exercise intolerance in heart failure (HF) reflects combined cardiac and skeletal muscle abnormalities, but the molecular associations underlying concurrent remodeling remain unclear. We examined cardiac and skeletal muscle phenotypes in a rat model of ischemic HF with global miR-133a deficiency and explored cand...

Wen Li, Yu-Wei Song, Zhou Zhou et al. · 0 citations
Review Open access Aug 2026

Significance of the PI3K/AKT pathway in coronary microvascular dysfunction and advances in natural compound therapeutic research 

Introduction: Coronary microvascular dysfunction (CMD) contributes to myocardial ischemia and adverse cardiovascular outcomes, but effective treatments remain limited. Objective: This review aims to clarify the role of the phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) pathway in CMD and assess the therapeutic p...

Yijia Du, Xujin Ning, Jingguo Ma et al. · 0 citations

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