Xian-Jun Fang

HSF1 inhibition potentiates the antifungal activity and proteome instability induced by the fungal Hsp110 inhibitor 2H

Fungal infections remain a major cause of morbidity and mortality worldwide; however, therapeutic options are limited and are increasingly compromised by antifungal resistance. Heat Shock Protein 110 kDa (Hsp110) is an essential molecular chaperone required for protein homeostasis (proteostasis) and fungal viability an...