Hydrogel-Based BMP-2 Delivery for Bone Regeneration: From Material Control to Biological and Translational Evaluation
Bone morphogenetic protein-2 (BMP-2) is a potent osteoinductive factor, but rapid loss of bioactivity, short local retention, burst release, and diffusion into surrounding tissues reduce dose efficiency and may necessitate supraphysiological doses associated with local adverse effects. Hydrogels offer tunable platforms...